Low sun exposure increases multiple sclerosis risk both directly and indirectly.

Abstract excerpt

OBJECTIVE: We aimed to study (1) to what extent the influence of low sun exposure on multiple sclerosis (MS) risk is mediated by low vitamin D levels; (2) whether low sun exposure or vitamin D deficiency act synergistically with HLA-DRB1*15:01 and absence of HLA-A*02:01. METHODS: We used two population-based case-control studies (7069 cases, 6632 matched controls). Subjects with different HLA alleles, sun...

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