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Article

Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study.

Histopathology - 1 Oct 2017

Lozada John R, Burke Kathleen A, Maguire Aoife, Pareja Fresia, Lim Raymond S, Kim Jisun, Gularte-Merida Rodrigo, Murray Melissa P, Brogi Edi, Weigelt Britta, Reis-Filho Jorge S, Geyer Felipe C

Abstract excerpt

AIMS: Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Conventional fibroadenomas (FAs) are underpinned by recurrent MED12 mutations in the stromal components of the lesions. The aim of this study was to investigate the genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28513873
DOI: 10.1111/his.13258
PMCID: PMC5597459

Genes

IMPACT
MED12

Provenance

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