Article
Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes.
Emerging infectious diseases - 1 Jan 2021
Wawina-Bokalanga Tony, Vanmechelen Bert, Lhermitte Valentine, Martí-Carreras Joan, Vergote Valentijn, Koundouno Fara Raymond, Akoi-Boré Joseph, Thom Ruth, Tipton Tom, Steeds Kimberley, Moussa Kéita Balla, Amento Ablam, Laenen Lies, Duraffour Sophie, Gabriel Martin, Ruibal Paula, Hall Yper, Kader-Kondé Mandy, Günther Stephan, Baele Guy, Muñoz-Fontela Cesar, Van Weyenbergh Johan, Carroll Miles W, Maes Piet
Abstract excerpt
We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating...
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