Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection.

doi:10.1371/journal.pone.0255608

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Article

Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection.

PloS one - 1 Jan 2021

Littera Roberto, Chessa Luchino, Deidda Silvia, Angioni Goffredo, Campagna Marcello, Lai Sara, Melis Maurizio, Cipri Selene, Firinu Davide, Santus Simonetta, Lai Alberto, Porcella Rita, Rassu Stefania, Meloni Federico, Schirru Daniele, Cordeddu William, Kowalik Marta Anna, Ragatzu Paola, Vacca Monica, Cannas Federica, Alba Francesco, Carta Mauro Giovanni, Del Giacco Stefano, Restivo Angelo, Deidda Simona, Palimodde Antonella, Congera Paola, Perra Roberto, Orrù Germano, Pes Francesco, Loi Martina, Murru Claudia, Urru Enrico, Onali Simona, Coghe Ferdinando, Giglio Sabrina, Perra Andrea

Abstract excerpt

BACKGROUND: The diversity in the clinical course of COVID-19 has been related to differences in innate and adaptative immune response mechanisms. Natural killer (NK) lymphocytes are critical protagonists of human host defense against viral infections. It would seem that reduced circulating levels of these cells have an impact on COVID-19 progression and severity. Their activity is strongly regulated by...

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PMID: 34352002
DOI: 10.1371/journal.pone.0255608
PMCID: PMC8341547

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