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Article

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection

28 Sept 2010

Abstract excerpt

Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical role for NK cells has been suggested but not elucidated. In this genetic study, we investigated...

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PMID: 20878400
DOI: 10.1007/s00251-010-0480-x

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