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A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency

12 Oct 2020

Abstract excerpt

Abstract For anthracycline-based chemotherapy to be immunogenic, dying cancer cells must release annexin A1 (ANXA1) that subsequently interacts with the pattern recognition receptor, formyl peptide receptor 1 (FPR1), on the surface of dendritic cells (DC). Approximately 30% of individuals bear loss-of-function alleles of FPR1, calling for strategies to ameliorate their anticancer immune response. Here, we show...

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PMID: 33046534
DOI: 10.1158/2159-8290.cd-20-0465

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