Article
Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease.
Future microbiology - 1 Jan 2015
Jaeger Martin, Stappers Mark H T, Joosten Leo A B, Gyssens Inge C, Netea Mihai G
Abstract excerpt
Cells of the innate immune system are equipped with surface and cytoplasmic receptors for microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns and as such are crucial for the activation of the immune system. Currently, five different classes of PRRs have been described: Toll-like receptors, C-type lectin receptors, nucleotide-binding...
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