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Article

Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells.

Blood advances - 12 Nov 2019

Sewastianik Tomasz, Guerrera Maria Luisa, Adler Keith, Dennis Peter S, Wright Kyle, Shanmugam Vignesh, Huang Ying, Tanton Helen, Jiang Meng, Kofides Amanda, Demos Maria G, Dalgarno Audrey, Patel Neil A, Nag Anwesha, Pinkus Geraldine S, Yang Guang, Hunter Zachary R, Jarolim Petr, Munshi Nikhil C, Treon Steven P, Carrasco Ruben D

Abstract excerpt

MYD88 L265P is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 pathway has an adverse impact on LPL/WM and DLBCL cell survival, its role in lymphoma initiation remains to be clarified. We show that in mice, human MYD88L265P...

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Source

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Identifiers

PMID: 31698464
DOI: 10.1182/bloodadvances.2019000588
PMCID: PMC6855113

Genes

LPL
MYD88

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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