Article
Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.
The Journal of experimental medicine - 4 Sept 2017
Wang James Q, Jeelall Yogesh S, Humburg Peter, Batchelor Emma L, Kaya Sarp M, Yoo Hee Min, Goodnow Christopher C, Horikawa Keisuke
Abstract excerpt
CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88L265P mutations individually and combined in normal activated mouse B lymphocytes. CD79B mutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.