Article
Cytokine gene functional polymorphisms and phenotypic expression as predictors of evolution from latent to clinical rheumatic heart disease.
Cytokine - 1 Feb 2021
Tormin Julia P A S, Nascimento Bruno R, Sable Craig A, da Silva Jose Luiz P, Brandao-de-Resende Camilo, Rocha Luiz Paulo C, Pinto Cecília H R, Neves Eula Graciele A, Macedo Frederico V B, Fraga Clara L, Oliveira Kaciane K B, Diamantino Adriana C, Ribeiro Antônio Luiz P, Beaton Andrea Z, Nunes Maria Carmo P, Dutra Walderez O
Abstract excerpt
INTRODUCTION: Inflammation associated with rheumatic heart disease (RHD) is influenced by gene polymorphisms and inflammatory cytokines. There are currently no immunologic and genetic markers to discriminate latent versus clinical patients, critical to predict disease evolution. Employing machine-learning, we searched for predictors that could discriminate latent versus clinical RHD, and eventually identify...
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