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Article

Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.

Communications biology - 18 Dec 2020

Yao Yao, Yang Jia, Qin Qian, Tang Chao, Li Zhidan, Chen Li, Li Kailong, Ren Chunyan, Chen Lu, Rao Shuquan

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple genomic loci linked to blood cell traits, however understanding the biological relevance of these genetic loci has proven to be challenging. Here, we performed a transcriptome-wide association study (TWAS) integrating gene expression and splice junction usage in neutrophils (N = 196) with a neutrophil count GWAS (N = 173,480 individuals). We...

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Identifiers

PMID: 33340029
DOI: 10.1038/s42003-020-01527-7
PMCID: PMC7749173

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