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Article

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

28 Jul 2017

Abstract excerpt

BACKGROUND: Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported to affect integration efficiency. LEDGF/p75-mediated targeting of the integration complex toward RNA polymerase II (polII) transcribed regions ensures optimal access to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28754126
DOI: 10.1186/s12977-017-0363-4

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