Article
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.
Cancer research - 15 Jan 2008
Memmott Regan M, Gills Joell J, Hollingshead Melinda, Powers Margaret C, Chen Zhiping, Kemp Bruce, Kozikowski Alan, Dennis Phillip A
Abstract excerpt
Loss of function of the tumor suppressor LKB1 occurs in 30% to 50% of lung adenocarcinomas. Because LKB1 activates AMP-activated protein kinase (AMPK), which can negatively regulate mTOR, AMPK activation might be desirable for cancer therapy. However, no known compounds activate AMPK independently of LKB1 in vivo, and the usefulness of activating AMPK in LKB1-mutant cancers is unknown. Here, we show that...
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