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Article

Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation.

Cancer research - 15 Aug 2018

Kim Ji Hye, Nam Boas, Choi Yun Jung, Kim Seon Ye, Lee Jung-Eun, Sung Ki Jung, Kim Woo Sung, Choi Chang-Min, Chang Eun-Ju, Koh Jae Soo, Song Joon Seon, Yoon Shinkyo, Lee Jae Cheol, Rho Jin Kyung, Son Jaekyoung

Abstract excerpt

Oncogenic EGFR is essential for the development and growth of non-small cell lung cancer (NSCLC), but the precise roles of EGFR in lung cancer metabolism remain unclear. Here, we show that EGFR mutation-mediated enhancement of glycolysis is critical for EGFR stability. EGFR knockdown significantly decreased levels of glycolytic pathway intermediates via transcriptional regulation of glycolytic genes. EGFR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29945964
DOI: 10.1158/0008-5472.CAN-18-0117

Genes

EGFR

Provenance

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