Article
Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Yang Ling, Ye Chun-Yan, Huang Xiao-Tian, Tang Xi-Can, Zhang Hai-Yan
Abstract excerpt
A number of recent discoveries indicate that huperzine A, an active herbal medicine employed for the treatment of Alzheimer's disease (AD) in China, can afford neuroprotection on in vitro and in vivo models related to mitochondrial dysfunction. However, it is an intricate and highly debated research topic about whether another pharmacological mechanism is involved in the beneficial profiles of huperzine A,...
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