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Article

Read trimming has minimal effect on bacterial SNP-calling accuracy.

Microbial genomics - 1 Dec 2020

Bush Stephen J

Abstract excerpt

Read alignment is the central step of many analytic pipelines that perform variant calling. To reduce error, it is common practice to pre-process raw sequencing reads to remove low-quality bases and residual adapter contamination, a procedure collectively known as 'trimming'. Trimming is widely assumed to increase the accuracy of variant calling, although there are relatively few systematic evaluations of its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33332257
DOI: 10.1099/mgen.0.000434
PMCID: PMC8116680

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