Article
Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor.
Scientific reports - 16 Dec 2020
Imhof Thomas, Rosenblatt Katharina, Pryymachuk Galyna, Weiland Daniela, Noetzel Nicolas, Deschner James, Baris Olivier R, Kimoloi Sammy, Koch Manuel, Wiesner Rudolf J, Korkmaz Yüksel
Abstract excerpt
The formation of dentin and enamel matrix depends on reciprocal interactions between epithelial-mesenchymal cells. To assess the role of mitochondrial function in amelogenesis and dentinogenesis, we studied postnatal incisor development in K320E-TwinkleEpi mice. In these mice, a loss of mitochondrial DNA (mtDNA), followed by a severe defect in the oxidative phosphorylation system is induced specifically in...
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