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Article

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.

Cell death & disease - 15 Dec 2020

Mukherjee Shravanti, Adhikary Santanu, Gadad Shrikanth S, Mondal Payel, Sen Sabyasachi, Choudhari Ramesh, Singh Vipin, Adhikari Swagata, Mandal Pratiti, Chaudhuri Soumi, Sengupta Amrita, Lakshmanaswamy Rajkumar, Chakrabarti Partha, Roy Siddhartha, Das Chandrima

Abstract excerpt

The major challenge in chemotherapy lies in the gain of therapeutic resistance properties of cancer cells. The relatively small fraction of chemo-resistant cancer cells outgrows and are responsible for tumor relapse, with acquired invasiveness and stemness. We demonstrate that zinc-finger MYND type-8 (ZMYND8), a putative chromatin reader, suppresses stemness, drug resistance, and tumor-promoting genes, which are...

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Identifiers

PMID: 33323928
DOI: 10.1038/s41419-020-03129-x
PMCID: PMC7738522

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