Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Cancer research - 15 Jul 2014

Kottakis Filippos, Foltopoulou Parthena, Sanidas Ioannis, Keller Patricia, Wronski Ania, Dake Benjamin T, Ezell Scott A, Shen Zhu, Naber Stephen P, Hinds Philip W, McNiel Elizabeth, Kuperwasser Charlotte, Tsichlis Philip N

Abstract excerpt

The JmjC domain histone H3K36me2/me1 demethylase NDY1/KDM2B is overexpressed in various types of cancer. Here we show that knocking down NDY1 in a set of 10 cell lines derived from a broad range of human tumors inhibited their anchorage-dependent and anchorage-independent growth by inducing senes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer of Zeste Homolog 2 Protein
Share to F-Box Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Immunophenotyping

Share to Jumonji Domain-Containing Histone Demethylases

Share to Neoplastic Stem Cells

Share to Polycomb-Group Proteins

Share to Polycomb Repressive Complex 2

Source

Open in PubMed Open full text

Identifiers

PMID: 24853546
DOI: 10.1158/0008-5472.CAN-13-2733
PMCID: PMC4454481

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24853546-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.PMID 24853546Read ↗

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programsSemantic proximity Read ↗

JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma CellsSemantic proximity Read ↗

A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemiaSemantic proximity Read ↗

DDB2 Suppresses Tumorigenicity by Limiting the Cancer Stem Cell Population in Ovarian CancerSemantic proximity Read ↗

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.Semantic proximity Read ↗

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1Semantic proximity Read ↗

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progressionSemantic proximity Read ↗

Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancerSemantic proximity Read ↗

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.Semantic proximity Read ↗

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesisSemantic proximity Read ↗

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow TransplantationSemantic proximity Read ↗

Cell Fate Determination Factor Dachshund Reprograms Breast Cancer Stem Cell FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.