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Article

CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort.

Cancer investigation - 1 Apr 2026

Manav Yigit Zehra, Dikbas Osman Semih, Mergen Fatih, Bozkurt Gokay, Gumus Evren

Abstract excerpt

CHEK2 is a moderate-penetrance tumor suppressor gene primarily linked to hereditary breast cancer, yet growing evidence implicates it in a wider tumor spectrum. Data from underrepresented populations, such as Türkiye, remains limited. We retrospectively analyzed 895 individuals referred for hereditary cancer evaluation between 2019 and 2025 who underwent multigene panel testing. Germline CHEK2 variants were...

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Identifiers

PMID: 41416706
DOI: 10.1080/07357907.2025.2600078

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort.PMID 41416706Read ↗

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