Compensatory Response of the Somatotropic Axis from IGFBP-2b Gene Editing in Rainbow Trout (Oncorhynchus mykiss).

doi:10.3390/genes11121488

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Article

Compensatory Response of the Somatotropic Axis from IGFBP-2b Gene Editing in Rainbow Trout (Oncorhynchus mykiss).

Genes - 10 Dec 2020

Cleveland Beth M, Habara Shiori, Oikawa Jin, Radler Lisa M, Shimizu Munetaka

Abstract excerpt

Rainbow trout with gene editing-induced reductions in serum insulin-like growth factor binding protein (IGFBP)-2b exhibit similar growth performance compared to fish without IGFBP-2b gene disruption. The objective of this study is to determine how the components of the insulin-like growth factor (IGF)/IGFBP system respond to a reduction in serum IGFBP-2b abundance. Editing the IGFBP-2b genes in rainbow trout...

Topics

Animals
Fish Proteins
Gene Editing
Gene Expression Regulation
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor I
Muscle, Skeletal
Mutation
Oncorhynchus mykiss
Signal Transduction

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Identifiers

PMID: 33322039
DOI: 10.3390/genes11121488
PMCID: PMC7763687

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