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Visium spatial transcriptomics reveals intratumor heterogeneity and profiles of Gleason score progression in prostate cancer

10 Nov 2023

Abstract excerpt

Prostate cancer (PCa) frequently presents as a multifocal disease within a single gland. Herein, the transcriptome-wide profiles of glandular epithelial (GE) cells of four PCa tissues with various Gleason scores (GSs) are analyzed with Visium spatial transcriptomics (ST). The genetic classifications across PCa section sites generally matched the spatial patterns of histological structures with different GSs....

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PMID: 38077153
DOI: 10.1016/j.isci.2023.108429

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