Article
Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1.
Nucleic acids research - 11 Mar 1995
Chao S F, Chan V L, Juranka P, Kaplan A H, Swanstrom R, Hutchison C A
Abstract excerpt
We have analyzed 154 single amino acid replacement mutants within a 40 amino acid region (residues 164-203) of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). This region consists of two antiparallel beta-strands (strands 9 and 10) flanked by two alpha helices (E...
Topics
- Amino Acid Sequence
- Catalysis
- Crystallography, X-Ray
- Escherichia coli
- HIV Reverse Transcriptase
- HIV-1
- Molecular Sequence Data
- Mutation
- Protein Conformation
- RNA-Directed DNA Polymerase