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Article

Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1.

Nucleic acids research - 11 Mar 1995

Chao S F, Chan V L, Juranka P, Kaplan A H, Swanstrom R, Hutchison C A

Abstract excerpt

We have analyzed 154 single amino acid replacement mutants within a 40 amino acid region (residues 164-203) of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). This region consists of two antiparallel beta-strands (strands 9 and 10) flanked by two alpha helices (E and F). The structure of this region of the 'palm' subdomain is conserved in a variety of DNA and RNA polymerases,...

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Identifiers

PMID: 7535923
DOI: 10.1093/nar/23.5.803
PMCID: PMC306763

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