Next-generation sequencing of HLA: validation and identification of new polymorphisms in a Brazilian population.

doi:10.1111/tan.13880

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Article

Next-generation sequencing of HLA: validation and identification of new polymorphisms in a Brazilian population.

HLA - 1 Jul 2020

Fabreti-Oliveira Raquel A, Oliveira Cintia K F, Vale Eliane M G, Nascimento Evaldo

Abstract excerpt

BACKGROUND: Next-generation sequencing (NGS) is the most modern sequencing technique that has revolutionized HLA typing, providing high-resolution results with low ambiguity rates. This study aimed to show the experiences and challenges of an HLA laboratory in the validation process of the NGS me...

Topics

Alleles
Brazil
Genes, MHC Class I
HLA Antigens
High-Throughput Nucleotide Sequencing
Histocompatibility Testing
Humans

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