Article
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Nature communications - 1 Jan 2013
Lapierre Louis R, De Magalhaes Filho C Daniel, McQuary Philip R, Chu Chu-Chiao, Visvikis Orane, Chang Jessica T, Gelino Sara, Ong Binnan, Davis Andrew E, Irazoqui Javier E, Dillin Andrew, Hansen Malene
Abstract excerpt
Autophagy is a cellular recycling process that has an important anti-aging role, but the underlying molecular mechanism is not well understood. The mammalian transcription factor EB (TFEB) was recently shown to regulate multiple genes in the autophagy process. Here we show that the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans and, in addition, has a key role in lifespan...
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