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Transcriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells

14 Dec 2020

Abstract excerpt

The excessive accumulation of extracellular matrix (ECM) is a key feature of liver fibrosis and the activated hepatic stellate cells (HSCs) are the major producer of ECM proteins. However, the precise mechanisms and target molecules that are involved in liver fibrosis remain unclear. In this study, we reported that activating transcription factor 3 (ATF3) was over-expressed in mice and human fibrotic livers, in...

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PMID: 33311456
DOI: 10.1038/s41419-020-03271-6

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