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Article

The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition.

Journal of molecular biology - 5 Feb 2021

Hattori Takamitsu, Koide Akiko, Noval Maria G, Panchenko Tatyana, Romero Larizbeth A, Teng Kai Wen, Tada Takuya, Landau Nathaniel R, Stapleford Kenneth A, Koide Shohei

Abstract excerpt

The COVID-19 pandemic remains a global threat, and host immunity remains the main mechanism of protection against the disease. The spike protein on the surface of SARS-CoV-2 is a major antigen and its engagement with human ACE2 receptor plays an essential role in viral entry into host cells. Consequently, antibodies targeting the ACE2-interacting surface (ACE2IS) located in the receptor-binding domain (RBD) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33310017
DOI: 10.1016/j.jmb.2020.166748
PMCID: PMC7833242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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