Article
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2006
Miller Timothy M, Kim Soo H, Yamanaka Koji, Hester Mark, Umapathi Priya, Arnson Hannah, Rizo Liza, Mendell Jerry R, Gage Fred H, Cleveland Don W, Kaspar Brian K
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive paralysis arising from the premature death of motor neurons. An inherited form is caused by a dominant mutation in the ubiquitously expressed superoxide dismutase (SOD1). SOD1 mutant expression within motor neurons is a determinant of onset and early disease, and mutant accumulation within microglia accelerates disease progression. Muscle also is a...
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