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Article

A naturally occurring point mutation in the rocA gene of Streptococcus pyogenes confers the highly virulent phenotype.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Apr 2021

Yoshida Haruno, Takahashi Takashi, Matsui Hidenori

Abstract excerpt

INTRODUCTION: Mucoid (MTB313) and nonmucoid (MTB314) strains of group A streptococcus (GAS) emm (antiphagocytic M protein) type 1 were simultaneously isolated from a single patient suffering from streptococcal meningitis. In a CD46-expressing transgenic (CD46 Tg) mouse model of subcutaneous infection into both hind footpads with MTB313 or MTB314, MTB313 showed considerably higher virulence than MTB314. METHODS:...

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Identifiers

PMID: 33309630
DOI: 10.1016/j.jiac.2020.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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