Article

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

2020-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure and function, as well as the pathogenic mechanisms, remain unclear. We determined the crystal structure of the complete human GDAP1 core domain, which shows a novel mode of di...

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Literature Corpus work: 8e639c90-1f4f-57ac-b918-6c7c52517bd3
DOI: 10.1101/2020.11.13.381293

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