Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein interaction perturbation profiling at amino-acid resolution.

Nature methods - 1 Dec 2017

Woodsmith Jonathan, Apelt Luise, Casado-Medrano Victoria, Özkan Ziya, Timmermann Bernd, Stelzl Ulrich

Abstract excerpt

The identification of genomic variants in healthy and diseased individuals continues to rapidly outpace our ability to functionally annotate these variants. Techniques that both systematically assay the functional consequences of nucleotide-resolution variation and can scale to hundreds of genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bardet-Biedl Syndrome
Share to Amino Acid Sequence
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Protein Interaction Mapping

Share to Protein Interaction Maps

Share to Protein Subunits

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 29039417
DOI: 10.1038/nmeth.4464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-29039417-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein interaction perturbation profiling at amino-acid resolution.PMID 29039417Read ↗

Decoding the cellular effects of genetic variation through interaction proteomics.Semantic proximity Read ↗

A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.Semantic proximity Read ↗

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutationsSemantic proximity Read ↗

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data setSemantic proximity Read ↗

Mechanistic Mutational Scanning to Uncover the Secret Life of Proteins.Semantic proximity Read ↗

Proteome-wide identification of amino acid substitutions deleterious for protein functionSemantic proximity Read ↗

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.Semantic proximity Read ↗

Proteome-scale characterisation of motif-based interactome rewiring by disease mutationsSemantic proximity Read ↗

Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq.Semantic proximity Read ↗

Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids.Semantic proximity Read ↗

Clinical and Genetic Characterization of a Russian Family with Bardet-Biedl Syndrome Carrying a Previously Undescribed Missense Variant and a Recurrent Pathogenic Frameshift Variant in BBS7 Gene.Semantic proximity Read ↗

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.