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Article

Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.

Thrombosis and haemostasis - 1 Apr 2021

Vilar Rui, Lukowski Samuel W, Garieri Marco, Di Sanza Corinne, Neerman-Arbez Marguerite, Fish Richard J

Abstract excerpt

Thrombosis is a leading cause of morbidity and mortality. Fibrinogen, the soluble substrate for fibrin-based clotting, has a central role in haemostasis and thrombosis and its plasma concentration correlates with cardiovascular disease event risk and a prothrombotic state in experimental models. We aimed to identify chemical entities capable of changing fibrinogen production and test their impact on experimental...

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Identifiers

PMID: 33302304
DOI: 10.1055/s-0040-1718414
PMCID: PMC7982297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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