Article
A hydrophobic ratchet entrenches molecular complexes.
Nature - 1 Dec 2020
Hochberg Georg K A, Liu Yang, Marklund Erik G, Metzger Brian P H, Laganowsky Arthur, Thornton Joseph W
Abstract excerpt
Most proteins assemble into multisubunit complexes1. The persistence of these complexes across evolutionary time is usually explained as the result of natural selection for functional properties that depend on multimerization, such as intersubunit allostery or the capacity to do mechanical work2. In many complexes, however, multimerization does not enable any known function3. An alternative explanation is that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.