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Article

Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure

13 Aug 2020

Abstract excerpt

Background: Our previous GWAS identified genetic variants at six novel loci that were associated with a decline in left ventricular ejection fraction (LVEF), p<1x10-5 in 1,191 early breast cancer patients from the N9831 clinical trial of chemotherapy plus trastuzumab. In this study we sought replication of these loci. Methods: We tested the top loci from the GWAS for association with chemotherapy-related heart...

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PMID: 32903434
DOI: 10.3389/fcvm.2020.00142

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