Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

7 Dec 2020

Abstract excerpt

The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019 (COVID-19), a global healthcare and economic catastrophe. Understanding of the host immune response to SARS-CoV-2 is still in its infancy. A 382-nt deletion strain lacking ORF8 (Δ382 herein) was isolated in Singapore in March 2020. Infection with Δ382 was associated with less severe disease in patients, compared to infection with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune responses and vaccinations
Share to Respiratory viral infections research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33284849
DOI: 10.1371/journal.ppat.1009130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesPMID 33284849Read ↗

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read ↗

Immune Landscape of 382-Nt Deleted SARS-CoV-2 Reveals Heightened Adaptive Response Indicating Prophylactic Potential Against COVID-19Semantic proximity Read ↗

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19Semantic proximity Read ↗

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read ↗

Comprehensive comparison of transcriptomes in SARS-CoV-2 infection: alternative entry routes and innate immune responsesSemantic proximity Read ↗

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral loadSemantic proximity Read ↗

Human nasal and lung tissues infected <i>ex vivo</i> with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tractSemantic proximity Read ↗

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epitheliumSemantic proximity Read ↗

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epitheliumSemantic proximity Read ↗

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read ↗

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2.Semantic proximity Read ↗

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.