Article
Clinicopathological associations and prognostic values of IDH1 gene mutation, MGMT gene promoter methylation, and PD-L1 expressions in high-grade glioma treated with standard treatment.
The Pan African medical journal - 1 Jan 2020
July Julius, Patricia Diana, Gunawan Pricilla Yani, Setiajaya Handrianto, Ginting Teridah Ernala, Putra Teguh Pribadi, Wuisan Zerlina, Budhiarko Dini, Masykura Najmiatul, Prayogi Gintang, Utomo Ahmad Rusdan, Tandean Steven, Loe Michael Lumintang
Abstract excerpt
INTRODUCTION: the objective was to evaluate the impact of IDH1 R132H mutation, MGMT methylation and PD-L1 expression in high grade glioma that received standard therapy (surgery, radiation and chemotherapy) to overall survival (OS). METHODS: this is a retrospective study of 35 high grade glioma cases. Genotyping of IDH1 gene alteration on the mutation hotspot R132 (Sanger sequencing method with Applied Biosystems...
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