Article
Intra-tumor genetic heterogeneity in Wilms tumor samples.
Revista da Associacao Medica Brasileira (1992) - 1 Dec 2019
de Sá Pereira Bruna M, Azevedo Rafaela Montalvão de, Aguirre Neto Joaquim Caetano de, Menezes Clarice Franco, Rodrigues Karla Emília, Faria Paulo A, Camargo Beatriz de, Maschietto Mariana
Abstract excerpt
Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms' tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.