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Article

Population-Specific Immunogenomic Alterations in Gallbladder Cancer and Prognostic Significance.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2025

Zhu Yan, Solis Soto Luisa Maren, Pant Shubham, Vega Eduardo A, Vinuela Eduardo, Bozorgui Behnaz, Vauthey Jean-Nicolas, Aguayo Gloria, Wang Zhonglin, Lu Wei, Chen Xinyue, Mino Barbara, Kakarala Lakshmi, Dai Jianliang, Liu Suyu, Wani Khalida M, Lazar Alexander J, Carapeto Fernando, Lee Sunyoung, Wistuba Ignacio, Korkut Anil, Javle Milind, Kwong Lawrence N

Abstract excerpt

Gallbladder carcinoma is a deadly disease with a poor prognosis, and recent clinical data suggest only a modest benefit of PD1/PDL1 inhibitors in this disease. Optimizing immunotherapeutic approaches will require a detailed understanding of the immunogenomic landscape of this disease worldwide. We combined targeted next-generation sequencing and immunohistochemistry to create detailed immunogenomic landscapes...

Read the complete abstract on PubMed

Topics

Humans
Gallbladder Neoplasms
Biomarkers, Tumor
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Mutation

Prognosis

Aged

Middle Aged

Immunohistochemistry

United States

Adult

Source

Identifiers

PMID: 40541865
DOI: 10.1016/j.modpat.2025.100824

Genes

CD4
ERBB2
ARID1A
ARID2
ATM
CCND1
CCNE1
CD68
CDK4
KRAS
MDM2
NF1
PIK3CA
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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