Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression.

Nature genetics - 1 Aug 2025

Zhou Tao, Wu Yanhong, Li Shuai, Qiu Xinyao, Liu Erdong, Xie Zhihua, Shi Xuebing, Zhang Yani, Ma Guosheng, Guo Wenbo, Wang Xiang, Wang Kaiting, Yao Xiaomeng, Hu Ji, Shen Siyun, Yang Shuai, Jiang Xiaoqing, Fu Jing, Wang Hongyang, Gu Jin, Chen Lei

Abstract excerpt

Gallbladder carcinoma (GBC) is the most aggressive biliary tract cancer and is associated with a high mortality rate. Treatment of GBC faces therapeutic challenges owing to the elusive nature of in situ drivers within the local tumor microenvironment that drive its progression. Here, we created a single-cell atlas of 1,117,245 cells and a mutational landscape from 102 patients, which unveiled spatial-temporal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA modifications and cancer

Source

Identifiers

PMID: 40571730
DOI: 10.1038/s41588-025-02236-9

Genes

AREG
CXCL5
EGFR
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progressionPMID 40571730Read ↗

Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer.Semantic proximity Read ↗

miRNAs orchestration of gallbladder cancer – Particular emphasis on diagnosis, progression and drug resistanceSemantic proximity Read ↗

Integrative molecular characterisation of gallbladder cancer reveals micro-environment-associated subtypes.Semantic proximity Read ↗

Genetic landscape of gallbladder cancer: Global overviewSemantic proximity Read ↗

Molecular Classification and Tumor Microenvironment Characterization of Gallbladder Cancer by Comprehensive Genomic and Transcriptomic AnalysisSemantic proximity Read ↗

Integrated Omics of Metastatic Colorectal CancerSemantic proximity Read ↗

Disparities in Gallbladder Cancer: Epidemiology, Molecular Mechanisms, and Clinical Implications.Semantic proximity Read ↗

A comprehensive multi-omics study reveals potential prognostic and diagnostic biomarkers for colorectal cancerSemantic proximity Read ↗

Applications and advances of multi-omics technologies in gastrointestinal tumorsSemantic proximity Read ↗

Integrative Molecular Insights Into Epidemiological, Genetic, and Metabolic Risk Factors of Gallbladder Cancer: Implications for Biomarkers, Therapeutic Targeting, and Future Perspectives.Semantic proximity Read ↗

Population-Specific Immunogenomic Alterations in Gallbladder Cancer and Prognostic Significance.Semantic proximity Read ↗

Multi-omics analysis identifies CLDN1 as a key regulator of gallbladder cancer progression and prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.