Article
Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease.
Science (New York, N.Y.) - 15 Jan 2021
Nakamura Tomohiro, Oh Chang-Ki, Liao Lujian, Zhang Xu, Lopez Kevin M, Gibbs Daniel, Deal Amanda K, Scott Henry R, Spencer Brian, Masliah Eliezer, Rissman Robert A, Yates John R, Lipton Stuart A
Abstract excerpt
Here we describe mechanistically distinct enzymes (a kinase, a guanosine triphosphatase, and a ubiquitin protein hydrolase) that function in disparate biochemical pathways and can also act in concert to mediate a series of redox reactions. Each enzyme manifests a second, noncanonical function-transnitrosylation-that triggers a pathological biochemical cascade in mouse models and in humans with Alzheimer's disease...
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