Article
Genetic biomarkers of drug resistance: A compass of prognosis and targeted therapy in acute myeloid leukemia.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2020
Long Luyao, Assaraf Yehuda G, Lei Zi-Ning, Peng Hongwei, Yang Lin, Chen Zhe-Sheng, Ren Simei
Abstract excerpt
Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy with complex heterogenous genetic and biological nature. Thus, prognostic prediction and targeted therapies might contribute to better chemotherapeutic response. However, the emergence of multidrug resistance (MDR) markedly impedes chemotherapeutic efficacy and dictates poor prognosis. Therefore, prior evaluation of chemoresistance is of...
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