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Article

Mycobacterium vaccae Lysate Induces Anti-Allergic Immune Response In Vitro.

Bulletin of experimental biology and medicine - 1 Dec 2020

Strygin A V, Nesmiyanov P P, Petrov V I, Tolkachev B E, Morkovin E I, Gutov M V, Strygina A O

Abstract excerpt

Mycobacterium vaccae is a soil saprophyte which exerts anti-allergic properties. There are data that mechanism of action of M. vaccae when used in the treatment of human and animal allergic diseases is associated with Th1-phenotype switch. Here we studied the properties of sonicated M. vaccae lysate in co-cultures of dendritic cells and CD4+T cells. M. vaccae lysate stimulated IL-10 synthesis in co-cultures and...

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PMID: 33270158
DOI: 10.1007/s10517-020-05039-6

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