Article
Malfunctioning of the iron-sulfur cluster assembly machinery in Saccharomyces cerevisiae produces oxidative stress via an iron-dependent mechanism, causing dysfunction in respiratory complexes.
PloS one - 1 Jan 2014
Gomez Mauricio, Pérez-Gallardo Rocío V, Sánchez Luis A, Díaz-Pérez Alma L, Cortés-Rojo Christian, Meza Carmen Victor, Saavedra-Molina Alfredo, Lara-Romero Javier, Jiménez-Sandoval Sergio, Rodríguez Francisco, Rodríguez-Zavala José S, Campos-García Jesús
Abstract excerpt
Biogenesis and recycling of iron-sulfur (Fe-S) clusters play important roles in the iron homeostasis mechanisms involved in mitochondrial function. In Saccharomyces cerevisiae, the Fe-S clusters are assembled into apoproteins by the iron-sulfur cluster machinery (ISC). The aim of the present stud...
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