Article
Simultaneous Identification of Cell of Origin, Translocations, and Hotspot Mutations in Diffuse Large B-Cell Lymphoma Using a Single RNA-Sequencing Assay.
American journal of clinical pathology - 26 Apr 2021
Crotty Rory, Hu Krista, Stevenson Kristen, Pontius Maggie Y, Sohani Aliyah R, Ryan Russell J H, Rueckert Erroll, Brauer Heather A, Hudson Briana, Berlin Aaron M, Rodenbaugh Matt, Licon Abel, Haimes Josh, Iafrate A John, Nardi Valentina, Louissaint Abner
Abstract excerpt
OBJECTIVES: Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with a heterogenous genetic landscape that can require multiple assays to characterize. We reviewed a 1-step RNA-based assay to determine cell of origin (COO), detect translocations, and identify mutations and to assess the role of the assay in diagnosis. METHODS: Using a single custom Archer FusionPlex Lymphoma panel, we...
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