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Article

Validation of the Double-Hit Gene Expression Signature (DLBCL90) in an Independent Cohort of Patients with Diffuse Large B-Cell Lymphoma of Germinal Center Origin.

The Journal of molecular diagnostics : JMD - 1 May 2021

Nguyen Ha, Perry Anamarija, Skrabek Pamela, Nasr Michel, Herrera Alex F, Bedell Victoria, Murata-Collins Joyce, Pillai Raju, Xu Minlin, Chen Lu, Chan Wing C, Weisenburger Dennis D, Scott David W, Song Joo Y

Abstract excerpt

The prognosis of diffuse large B-cell lymphoma (DLBCL) has been associated with clinical parameters, cell of origin, and various genetic aberrations. Recently, a NanoString gene expression assay (DLBCL90) was developed, which identifies DLBCL cases with an outcome similar to those with double- or triple-hit DLBCL with both MYC and BCL2 rearrangements. This study validates the predictive ability of the DLBCL90...

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Share to Antineoplastic Combined Chemotherapy Protocols
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Germinal Center

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 33636392
DOI: 10.1016/j.jmoldx.2021.02.005
PMCID: PMC8185969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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