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Article

Prediction and characterization of diffuse large B-cell lymphoma cell-of-origin subtypes using targeted sequencing.

Future oncology (London, England) - 1 Nov 2021

Trabucco Sally E, Sokol Ethan S, Maund Sophia L, Moore Jay A, Frampton Garrett M, Albacker Lee A, Oestergaard Mikkel Z, Venstrom Jeffrey, Sehn Laurie H, Bolen Christopher R

Abstract excerpt

The aim of the present study was to determine cell of origin (COO) from a platform using a DNA-based method, COO DNA classifier (COODC). A targeted exome-sequencing platform that applies the mutational profile of a sample was used to classify COO subtype. Two major mutational signatures associated with COO were identified: Catalogue of Somatic Mutations in Cancer (COSMIC) signature 23 enriched in activated B cell...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Lymphocyte Activation

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 34313135
DOI: 10.2217/fon-2021-0370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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