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Article

Downregulation of PIK3CB Involved in Alzheimer’s Disease via Apoptosis, Axon Guidance, and FoxO Signaling Pathway

1 Jan 2022

Abstract excerpt

OBJECTIVE: To investigate the molecular function of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB) underlying Alzheimer's disease (AD). METHODS: RNA sequencing data were used to filtrate differentially expressed genes (DEGs) in AD/nondementia control and PIK3CB-low/high groups. An unbiased coexpression network was established to evaluate module-trait relationships by using weight...

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PMID: 35096262
DOI: 10.1155/2022/1260161

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