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Article

Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.

Molecular metabolism - 1 Feb 2021

Hasan Nesrin M, Johnson Kelli F, Yin Jianyi, Baetz Nicholas W, Fayad Lea, Sherman Vadim, Blutt Sarah E, Estes Mary K, Kumbhari Vivek, Zachos Nicholas C, Kovbasnjuk Olga

Abstract excerpt

OBJECTIVE: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models are suboptimal with respect to their ability to replicate the human intestinal epithelium under conditions induced by obesity. Human enteroids have the potential to accelerate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33246140
DOI: 10.1016/j.molmet.2020.101129
PMCID: PMC7770968

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