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Article

Modeling the effects of hyaluronic acid degradation on the regulation of human astrocyte phenotype using multicomponent interpenetrating polymer networks (mIPNs).

Scientific reports - 26 Nov 2020

Jimenez-Vergara Andrea C, Van Drunen Rachel, Cagle Tyler, Munoz-Pinto Dany J

Abstract excerpt

Hyaluronic acid (HA) is a highly abundant component in the extracellular matrix (ECM) and a fundamental element to the architecture and the physiology of the central nervous system (CNS). Often, HA degradation occurs when an overreactive inflammatory response, derived from tissue trauma or neurodegenerative diseases such as Alzheimer's, causes the ECM in the CNS to be remodeled. Herein, we studied the effects of...

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Identifiers

PMID: 33244148
DOI: 10.1038/s41598-020-77655-1
PMCID: PMC7691997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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