Article
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia.
Molecular brain - 26 Nov 2020
Hara Naoyuki, Morino Hiroyuki, Matsuda Yukiko, Satoh Kenichi, Hashimoto Kouichi, Maruyama Hirofumi, Kawakami Hideshi
Abstract excerpt
Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountered a patient with the p.Arg1715His mutation, suffering from intractable resting tremor, particularly head tremor. This symptom improved with the administration of low-dose of zonisamide (ZNS), a T-type...
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